12 peer-reviewed SCI publications across journals of international repute. Author name in blue denotes Ayan Acharya. DOI links provided for all published work.
01
Thesis Research
Cyclopropyl-1,1-dinitrile as Five-Atom Synthon: Regioselective Ring-Opening and a Keteneimine-Enamine Based Nitrile-to-Nitrile Condensation Affording an Entry to Pyridines
Ayan Acharya, Mithilesh Nagpure, Kriti Mehta, Savita Negi, Prasad V. Bharatam, and Sankar K. Guchhait*
Journal of Organic Chemistry (JOC)
Under Revision
02
Thesis Research
Bis-Indolyl Methane Natural Product-Inspired Scaffold Hopped Analogs — Indolyl-Arylmethyl-Imidazo[1,2-a]pyridines: Discovery of Synthetic Method and Bioevaluation Studies for Anticancer Activities
Ayan Acharya, Santanu Basak, Santosh Guru, and Sankar K. Guchhait*
Manuscript in Preparation
03
Thesis Research
Combretastatin A-4 Natural Product-Inspired Pseudo-Natural Products — Combretapyrroles: Discovery of Synthetic Method and Bioevaluation Studies for Anticancer Activities
Ayan Acharya, Satyajit Haldar, Kuladip Jana, and Sankar K. Guchhait*
Manuscript in Preparation
04
Thesis Research
Synthesis of Diarylpyrrole Pseudo-Natural Products: Cyanide-Mediated Nitrile-to-Nitrile Cyclocondensation and C-H Acidity-Guided Regioselectivity
Debanjan Singha‡, Tanmay Kundu‡, Ayan Acharya‡, Sankar K. Guchhait* (‡ equally contributed)
05
Perspective
Biosynthetically Natural Product-Conserved Scaffolds: Harnessing Power with Molecular-Medicinal Strategy for New Therapeutic Development
Ayan Acharya, Vaibhav Gupta, Mithilesh Nagpure, and Sankar K. Guchhait*
06
Perspective
How to Nurture Natural Products to Create New Therapeutics? Strategic Innovations and Molecule-to-Medicinal Insights into Therapeutic Advancements
Ayan Acharya, Mithilesh Nagpure, Nibedita Roy, Vaibhav Gupta, Soumadeep Patranabis, Sankar K. Guchhait*
07
Perspective
Molecular Medicinal Insights into Scaffold Hopping-Based Drug Discovery Success
Ayan Acharya, Mukul Yadav, Mithilesh Nagpure, Santhanalaxmi Kumaresan, Sankar K. Guchhait*
08
Review Article
Topoisomerase II-Targeting Anticancer Clinical Candidates and Drugs: A Critical Analysis, Unravelling Molecular Medicinal Insights and Promising Research Roadmap
Ayan Acharya, Nibedita Roy, Vaishnavi Newaskar, Abhishek Rai, Abhrajyoti Ghosh, Mithilesh Nagpure, Santosh Kumar Giri, Gautam Sahni, Sankar K. Guchhait*
09
Allied Work
Natural Product Inspired Scaffold Hopping Strategy: Identification of Potent Anticancer 2-Arylpyridopyrimidinones that Induce Cytoplasmic and Mitochondrial ROS and G₂/M Arrest
Gulshan Kumar, Satyajit Haldar, Ayan Acharya, Chirantan Majumder, Kuladip Jana*, and Sankar K. Guchhait*
10
Allied Work
Scaffold-Hopping of Natural Alkaloid Rutaecarpine: Synthesis and Anticancer-Apoptosis and Autophagy Effects of Indole-Based Analogs
Mukul Yadav, Santanu Basak, Vaibhav Gupta, Sandesh Sarjerao, Ayan Acharya, Santosh Kumar Guru, Sankar K. Guchhait*
11
Allied Work
Scaffold Overlay of Flavonoid-Inspired Molecules: Discovery of 2,3-Diaryl-Pyridopyrimidin-4-Imine/Ones as Dual hTopo-II and Tubulin Targeting Anticancer Agents
Meenu Saini, Subarno Paul, Ayan Acharya, Sushree Subhadra Acharya, Chanakya Nath Kundu, Sankar K. Guchhait*
12
Allied Work
Development of QTMP: A Promising Anticancer Agent through NP-Privileged Motif-Driven Structural Modulation
Pritam Giri, Pooja J. Batra, Ayan Acharya, Anuradha Kumari, Neha Hura, Sankar Kumar Guchhait*, Dulal Panda*
13
Allied Work
Scaffold Hopping in Drug Discovery: Innovation in Pharma Industries and Academia
Santhanalaxmi Kumaresan, Jagroop Singh, Ayan Acharya, Mukul Yadav, Sankar K. Guchhait*
14
Allied Work
A Cascade Reaction of Indolyl-Migratory Isocyanide Insertion, Scaffold Rearrangement and Redox-Neutral Event with Isocyanide as a C(sp³)H–N Synthon Efficiently Constructs Indolylisoindolinones
Shailendra Sisodiya, Ayan Acharya, Mithilesh Nagpure, Nibedita Roy, Santosh K. Giri, Hare Ram Yadav, Angshuman R. Choudhury, Sankar K. Guchhait*
15
Allied Work
Organocatalyzed Umpolung Addition for Synthesis of Heterocyclic-Fused Arylidene-Imidazolones as Anticancer Agents
Gulshan Kumar, Chinmay Das, Ayan Acharya, Subhasmita Bhal, Mayank Joshi, Chanakya Nath Kundu, Angshuman Roy Choudhury, Sankar K. Guchhait
16
Allied Work
Identification of 2-Arylquinazolines with Alkyl-Polyamine Motifs as Potent Antileishmanial Agents: Synthesis and Biological Evaluation Studies
Anjila Kumari, Tara Jaiswal, Vinay Kumar, Neha Hura, Gulshan Kumar, Neerupudi Kishore Babu, Ayan Acharya, Pradyot K. Roy, Sankar Kumar Guchhait, Sushma Singh
17
Thesis Research
Diastereoselective [4+1] Annulation of 2-TosylAlkyl-Phenols with Nitrile-Stabilized Ammonium Ylides as Motifs-Transferring Synthons: A Route to Benzofurans and 2,3-Dihydrobenzofuran-2-carbonitriles
Mithilesh Nagpure, Ayan Acharya, Vaibhav Gupta, and Sankar K. Guchhait*
Manuscript in Preparation
18
Allied Work
Cu(II)-Catalyzed Regioselective Alkyne Hydro-oxygenation and C–P(V) Bond Formation of Alkynylphosphonates with Phenols: A Route to Phosphachromones
Vaibhav Gupta, Ayan Acharya, Mithilesh Nagpure, and Sankar K. Guchhait*
Manuscript in Preparation